Postdoc in Structural Biology : Mainz, Germany

A postdoc position in Structural Biology is available for 3 years (salary scale TV-L13) in the research group of Prof. Eva Wolf at University Mainz (JGU), Germany. The Wolf group is currently located at the Institute of Molecular Biology (IMB) Mainz (www.imb-mainz.de/wolf). Research in the Wolf group is focused Ｏn structural (mostly X-ray crystallography), biochemical and biophysical analyses of proteins involved in the regulation of circadian (24 h) rhythms. Projects will involve cloning, recombinant protein expression and purification, X-ray crystallography as well as complementary biochemical and biophysical methods to study protein structures, interactions and activities. The successful postdoctoral applicant will have solid practical experience in recombinant protein expression (insect cells, E.coli), protein purification and macromolecular X-ray crystallography. Additional experience with biochemical or biophysical analyses or cryo-EM of purified proteins is an advantage.

Description

A postdoc position is available in the laboratory of Prof. Eva Wolf at the Biology department of the Johannes Gutenberg University (JGU) Mainz, Germany. The position is available immediately for an initial period of 3 years. Salary will be according to German public service payment agreement (TV-L 13). Research in the Wolf group is focused Ｏn the structural (mostly X-ray crystallography), biochemical and biophysical analysis of proteins/protein complexes involved in the regulation and light-synchronization of the inner circadian clock (e.g. Czarna et al (2013) Cell,153(6):1394-405; Schmalen et al (2014) Cell,157(5):1203–1215). Circadian clocks generate daily (24 h) rhythms of physiology, metabolism and behaviour and thereby critically affect fitness, health and disease. We are also interested in molecular connections between circadian clocks and DNA replication, cell cycle and genome stability (Witosch et al (2014) Nucleic Acids Research, 42:12912-27). Projects will involve a wide range of techniques including cloning, recombinant protein expression, protein purification, crystallization and X-ray crystallography as well as complementary biochemical and biophysical methods to study protein structures, interactions and activities. The Wolf group is currently located at the Institute of Molecular Biology (IMB) (www.imb-mainz.de/wolf). IMB is a Centre of Excellence for Life Sciences, which is funded by the Boehringer Ingelheim Foundation and located Ｏn the campus of the Johannes Gutenberg University Mainz, Germany. The successful postdoc candidate will have solid practical experience in recombinant protein expression (preferentially using both insect cells and E.coli), in protein purification and in macromolecular X-ray crystallography. Additional experience with biochemical, biophysical or spectroscopic analyses of purified proteins or with cryo-EM is an advantage. She/he will hold a PhD in a relevant discipline.